A study on the chronopharmacokinetics of theophylline in rabbits.
نویسندگان
چکیده
The Chronopharmacokinetics of a single oral dose of theophylline was studied in rabbits. It was observed that morning (06.00 hr) dosing was characterized by significantly low rate of absorption (t 1/2a and Tmax) but higher extent of absorption (AUC0-alpha) compared to that after nocturnal dosing (22.00 hr). The plasma half life (t1/2el) was significantly less at night compared to that in daytime. The data may have considerable clinical relevance.
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 35 3 شماره
صفحات -
تاریخ انتشار 1991